Article
Skilled use of DNA polymorphisms as a tool for polygenic cancers.
Carcinogenesis - 1 Mar 2002
Hemminki Kari, Shields Peter G
Abstract excerpt
Association studies are assumed to be an efficient method of deciding whether a gene or its variant is important for cancer. Sequencing data on 30 000 human genes suggest that an average gene contains one to two single nucleotide polymorphisms (SNP), and high through-put technologies have become available for fast genotyping. Because no functional data are available for most SNPs, the result of the large-scale...
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