Article
Modeling human epilepsies in mice.
Epilepsia - 1 Jan 2001
Noebels J L
Abstract excerpt
Two categories of mouse models of human epilepsy are now contributing to the experimental analysis of inherited seizure disorders. The first type includes homologous genetic models arrived at in the classic way; the genes from human inherited epilepsy syndromes are cloned, and mice are recreated with functionally identical mutations. The second category involves the reverse strategy: mutating single genes in mice...
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