Article
T cell epitopes in coxsackievirus B4 structural proteins concentrate in regions conserved between enteroviruses.
Virology - 15 Feb 2002
Marttila Jane, Hyöty Heikki, Vilja Pekka, Härkönen Taina, Alho Annu, Roivainen Merja, Hyypiä Timo, Ilonen Jorma
Abstract excerpt
The present study aimed to characterize systematically the target epitopes of T cell responses in CBV4 structural proteins. These were studied by synthesizing 86 overlapping 20-aa-long peptides covering the known sequence of CBV4 structural proteins and analyzing the proliferation responses of 18 CBV4-specific T cell lines against these peptides. Recognized peptides differed depending on the HLA-DR genotype of...
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