Article
Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder.
American journal of human genetics - 1 Apr 2002
Shao Yujun, Raiford Kimberly L, Wolpert Chantelle M, Cope Heidi A, Ravan Sarah A, Ashley-Koch Allison A, Abramson Ruth K, Wright Harry H, DeLong Robert G, Gilbert John R, Cuccaro Michael L, Pericak-Vance Margaret A
Abstract excerpt
Autistic disorder (AutD) is a neurodevelopmental disorder characterized by significant disturbances in social, communicative, and behavioral functioning. A two-stage genomic screen analysis of 99 families with AutD revealed suggestive evidence for linkage to chromosome 2q (D2S116 nonparametric sib-pair LOD score [MLS] 1.12 at 198 cM). In addition, analysis of linkage disequilibrium for D2S116 showed an...
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