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Article

C1q deficiency and autoimmunity: the effects of genetic background on disease expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2002

Mitchell Daniel A, Pickering Matthew C, Warren Joanna, Fossati-Jimack Liliane, Cortes-Hernandez Josefina, Cook H Terence, Botto Marina, Walport Mark J

Abstract excerpt

Gene-targeted C1q-deficient mice have been shown to develop a syndrome reminiscent of human systemic lupus erythematosus with antinuclear Abs and proliferative glomerulonephritis. Initial phenotypic analysis conducted in (129 x C57BL/6) hybrid mice showed that background genes were a significant factor for the full expression of the autoimmune disease. To assess the contribution of background genes in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11859149
DOI: 10.4049/jimmunol.168.5.2538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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