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Article

Replication of Neisseria meningitidis within epithelial cells requires TonB-dependent acquisition of host cell iron.

Infection and immunity - 1 Mar 2002

Larson Jason A, Higashi Dustin L, Stojiljkovic Igor, So Magdalene

Abstract excerpt

Neisseria meningitidis (meningococcus [MC]) is able to enter and replicate within epithelial cells. Iron, an essential nutrient for nearly all organisms, is an important determinant in the ability of MC to cause disease; however, its role in MC intracellular replication has not been investigated. We analyzed the growth of MC within the A431 human epithelial cell line and the dependence of this growth on iron...

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Identifiers

PMID: 11854233
DOI: 10.1128/IAI.70.3.1461-1467.2002
PMCID: PMC127810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication of Neisseria meningitidis within epithelial cells requires TonB-dependent acquisition of host cell iron.PMID 11854233Read ↗

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