Article
N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication.
The Journal of general virology - 1 Mar 2002
Wagner Ralf, Heuer Dagmar, Wolff Thorsten, Herwig Astrid, Klenk Hans-Dieter
Abstract excerpt
The haemagglutinin (HA) protein of fowl plague virus A/FPV/Rostock/34 (H7N1) contains three N-linked oligosaccharide side chains in its stem domain. These stem glycans, which are attached to the Asn residues at positions 12, 28 and 478, are highly conserved throughout all HA protein sequences analysed to date. In a previous study, in which mutant HA proteins lacking individual stem glycosylation sites had been...
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