Article
Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002
Carroll Lara S, Penn Dustin J, Potts Wayne K
Abstract excerpt
Genes of the major histocompatibility complex (MHC) play a central role in immune recognition, yet they also influence the odor of individuals. Mice can be trained to distinguish odors mediated by classical MHC loci; however, training can introduce confounding behavioral artifacts. This study demonstrates that mice can distinguish some, but not all, naturally occurring allelic variants at classical MHC loci...
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