Article
Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2002
Tait Andy, Masiga Dan, Ouma Johnstone, MacLeod Annette, Sasse Juergen, Melville Sara, Lindegard Gabbi, McIntosh Anne, Turner Mike
Abstract excerpt
The genome of the African trypanosome, Trypanosoma brucei, is currently being sequenced, raising the question of how the data generated can be used to determine the function of the large number of genes that will be identified. There is a range of possible approaches, and in this paper we discuss the use of a classical genetic approach coupled with positional cloning based on the ability of trypanosomes to...
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