Article
Mutation of bcl-x gene in non-Hodgkin's lymphoma.
American journal of hematology - 1 Jan 2002
Yamaguchi Hiroki, Inokuchi Koiti, Tarusawa Miki, Dan Kazuo
Abstract excerpt
The bcl-x gene product has two forms, bcl-xl and bcl-xs. The bcl-xl form, similar to bcl-2, inhibits apoptosis. Reverse transcriptase-polymerase chain reaction/single-stranded conformation polymorphism (RT-PCR-SSCP) gel analysis was used to screen for mutations of the bcl-xl transcript of 50 non-Hodgkin's lymphoma (NHL) cases. One missense mutation in a patient with diffuse large B-cell lymphoma was found....
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