Article
In vitro reconstructed human epithelia reveal contributions of Candida albicans EFG1 and CPH1 to adhesion and invasion.
Microbiology (Reading, England) - 1 Feb 2002
Dieterich C, Schandar M, Noll M, Johannes F-J, Brunner H, Graeve T, Rupp S
Abstract excerpt
The individual and synergistic contributions of two transcription factors, EFG1 and CPH1, have been characterized with regard to adhesion to, and invasion of, human epithelia by Candida albicans. For this purpose two in vitro reconstructed tissue models were developed. A multi-layered model of human epidermis was used to simulate superficial infections of the skin, whereas a reconstructed human intestinal model...
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