Article
Hematologically important mutations: leukocyte adhesion deficiency.
Blood cells, molecules & diseases - 1 Jan 2000
Roos D, Law S K
Abstract excerpt
Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients with LAD suffer from severe bacterial infections and impaired wound healing. In LAD-I, mutations are found in INTG2, the gene that encodes the beta subunit of the beta(2) integrins. In the rare LAD-II disease, the fucosylation of...
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