Article
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells.
Blood - 15 Feb 2002
Tai Yu-Tzu, Podar Klaus, Gupta Deepak, Lin Boris, Young Gloria, Akiyama Masaharu, Anderson Kenneth C
Abstract excerpt
It was previously demonstrated that p53 status in human multiple myeloma (MM) cells regulates distinct cell cycle responses to CD40 activation. In this study, the production of vascular endothelial growth factor (VEGF) and migration in MM cells triggered by CD40 activation was examined, and the influence of p53 status in regulating this process was determined. Two human MM cell lines that express wild-type p53 at...
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