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Article

Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica.

Cancer letters - 28 Mar 2002

Ishihara Yoko, Iijima Hiroko, Matsunaga Kenichi, Fukushima Toshihiko, Nishikawa Toshio, Takenoshita Seiichi

Abstract excerpt

The genotoxic effect of crystalline silica (Qt) in the lung was studied to clarify that silicosis conferred a significant increase in risk subsequent lung cancer. C57BL/6N mice received a single tracheal injection of Qt at dose of 2 mg/mouse. Lung p53mRNA was suppressed significantly, but no change of p21mRNA 15 months after treatment. Mutation of p53 gene was not identified at 15 months in the Qt group....

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Identifiers

PMID: 11825659
DOI: 10.1016/s0304-3835(01)00779-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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