Cellular and molecular aspects of gastric cancer.

doi:10.3748/wjg.v12.i19.2979

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Article

Cellular and molecular aspects of gastric cancer.

World journal of gastroenterology - 21 May 2006

Smith Malcolm-G, Hold Georgina-L, Tahara Eiichi, El-Omar Emad-M

Abstract excerpt

Gastric cancer remains a global killer with a shifting burden from the developed to the developing world. The cancer develops along a multistage process that is defined by distinct histological and pathophysiological phases. Several genetic and epigenetic alterations mediate the transition from one stage to another and these include mutations in oncogenes, tumour suppressor genes and cell cycle and mismatch...

Topics

Cell Cycle Proteins
Cytokines
DNA Damage
Gene Expression Regulation, Neoplastic
Genes, Neoplasm
Genes, Tumor Suppressor
Growth Substances
Helicobacter Infections
Helicobacter pylori
Humans
Inflammation
Mutation
NF-kappa B
Neoplasm Metastasis
Proto-Oncogenes
Reactive Oxygen Species
Stomach Neoplasms
Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 16718776
DOI: 10.3748/wjg.v12.i19.2979
PMCID: PMC4124370

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