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Streptococcal β Protein Has Separate Binding Sites for Human Factor H and IgA-Fc

1 Apr 2002

Abstract excerpt

The group B streptococcus (GBS) is the most important cause of life-threatening bacterial infections in newborn infants. Protective immunity to GBS infection is elicited by several surface proteins, one of which, the beta protein, is known to bind human IgA-Fc. Here, we show that the beta protein also binds human factor H (FH), a negative regulator of complement activation. Absorption experiments with whole human...

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PMID: 11812795
DOI: 10.1074/jbc.m112072200

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