Article
Serotonin transporter gene polymorphism and psychiatric disorders in NF1 patients.
American journal of medical genetics - 8 Dec 2001
Bellivier F, Laplanche J L, Fournier G, Wolkenstein P
Abstract excerpt
Neurofibromatosis type 1 (NF1) is an autosomal-dominant genetic disease characterized by a broad clinical expression. Comorbid affective disorders, anxiety disorders, and suicide are frequently observed during NF1. The promoter marker (5-HTTLPR) of the serotonin transporter gene (5-HTT) has been shown to be associated with major affective disorders, anxiety-related trait, and more recently with suicidal behavior....
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