Article
Aberrant p53, mdm2, and proliferation differ in glioblastomas from long-term compared with typical survivors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2002
Burton Eric C, Lamborn Kathleen R, Forsyth Peter, Scott James, O'Campo Jason, Uyehara-Lock Jane, Prados Michael, Berger Mitchel, Passe Sandra, Uhm Joon, O'Neill Brian P, Jenkins Robert B, Aldape Ken D
Abstract excerpt
PURPOSE: Glioblastoma multiforme (GBM) is a highly lethal neoplasm with a median survival of approximately 1 year. Only 2-5% of patients originally diagnosed with GBM will survive > or = 3 years. Whether tumors from these long-term survivors (LTSs) exhibit molecular genetic differences compared with typical GBM survivors is not known. EXPERIMENTAL DESIGN: Tumors from 41 patients initially diagnosed with GBM and...
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