Article
Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro.
Infection and immunity - 1 Feb 2002
Guerry Patricia, Szymanski Christine M, Prendergast Martina M, Hickey Thomas E, Ewing Cheryl P, Pattarini Dawn L, Moran Anthony P
Abstract excerpt
The outer cores of the lipooligosaccharides (LOS) of many strains of Campylobacter jejuni mimic human gangliosides in structure. A population of cells of C. jejuni strain 81-176 produced a mixture of LOS cores which consisted primarily of structures mimicking GM(2) and GM(3) gangliosides, with minor amounts of structures mimicking GD(1b) and GD(2). Genetic analyses of genes involved in the biosynthesis of the...
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