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Article

Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity.

The Journal of biological chemistry - 22 Mar 2002

Hori Rio, Kashiba Misato, Toma Tomoko, Yachie Akihiro, Goda Nobuhito, Makino Nobuya, Soejima Akinori, Nagasawa Toshihiko, Nakabayashi Kimimasa, Suematsu Makoto

Abstract excerpt

Heme oxygenase (HO)-1 is a stress-inducible enzyme protecting cells against oxidative stress, and mechanisms have been considered to depend exclusively on its enzyme activity. This study aimed to examine if the protein lacking catalytic activities could also display such resistance against oxidative stress. Stable transfectants of rat wild type HO-1 cDNA (HO-1-U937) and those of its H25A mutant gene (mHO-1-U937)...

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PMID: 11786534
DOI: 10.1074/jbc.M107749200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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