Article
Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.
Science (New York, N.Y.) - 4 Jan 2002
Akama Tomoya O, Nakagawa Hiroaki, Sugihara Kazuhiro, Narisawa Sonoko, Ohyama Chikara, Nishimura Shin-Ichiro, O'Brien Deborah A, Moremen Kelley W, Millan Jose Luis, Fukuda Michiko N
Abstract excerpt
Spermatogenesis is a precisely regulated process in which the germ cells closely interact with Sertoli cells. The molecular basis of this cell-cell adhesion is unknown. Here, we demonstrate that targeted disruption of Man2a2, a gene encoding alpha-mannosidase IIx (MX), an enzyme that forms intermediate asparagine-linked carbohydrates (N-glycans), results in Man2a2 null males that are largely infertile. The Man2a2...
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