Article
Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan.
Clinical and diagnostic laboratory immunology - 1 Jan 2002
Ando Takafumi, Peek Richard M, Lee Yong-Chan, Krishna Uma, Kusugami Kazuo, Blaser Martin J
Abstract excerpt
Associations of Helicobacter pylori genotypes with disease differ between Western countries and Asia. Therefore, we directly compared histopathological and in vitro responses to clinical isolates with similar genotypes. Sixty-three cagA(+) vacAs1/m1 H. pylori isolates (United States, n = 24; Japan, n = 39) and eight cagA-negative vacAs2/m2 strains were incubated with AGS cells, and supernatants were assayed for...
Topics
- Adult
- Aged
- Antigens, Bacterial
- Apoptosis
- Bacterial Proteins
- DNA Fragmentation
- Female
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Interleukin-8
- Japan
- Male
- Middle Aged