Diversity within the CLC chloride channel family involved in inherited diseases: from plasma membranes to acidic organelles

Abstract excerpt

Since the first voltage‐gated ClC‐0 chloride channel was discovered by Jentsch et al. [1] in the marine ray Torpedo marmorata, nine chloride channels belonging to the CLC family have been identified in mammals [2]. These ClC channels exhibit marked differences in their tissue and cellular distribution. All ClC channels, except the ClC‐1 channel [2], are expressed in mammalian kidneys. They have important...

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