Phenotypic variation of retinal pigment epithelium in age-related macular degeneration.

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Article

Phenotypic variation of retinal pigment epithelium in age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Jan 2002

Guidry Clyde, Medeiros Nancy E, Curcio Christine A

Abstract excerpt

PURPOSE: To determine whether retinal pigment epithelium (RPE) in eyes with age-related macular degeneration (ARMD) express vimentin and alpha smooth muscle actin (alphaSMA), two cytoskeletal proteins associated with phenotypic variation in culture. METHODS: Six eyes with late ARMD and three age-matched control eyes were preserved in buffered 4% paraformaldehyde and cryosectioned at 10 microm. Stages of RPE...

Topics

Actins
Aged
Aged, 80 and over
Female
Fluorescent Antibody Technique, Indirect
Glial Fibrillary Acidic Protein
Humans
Macular Degeneration
Male
Phenotype
Pigment Epithelium of Eye
Vimentin

Source

Open in PubMed

Identifiers

PMID: 11773041

Genes

RPE
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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