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Article

Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2002

Koshizuka Yu, Kawaguchi Hiroshi, Ogata Naoshi, Ikeda Toshiyuki, Mabuchi Akihiko, Seichi Atsushi, Nakamura Yusuke, Nakamura Kozo, Ikegawa Shiro

Abstract excerpt

Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease that causes paralysis by compressing the spinal cord. Based on the fact that the nucleotide pyrophosphatase (Npps) gene is responsible for ectopic ossification in ttw, an OPLL model mouse, the possibility was explored whether the human NPPS gene is associated with susceptibility to and severity of OPLL. First, we screened for...

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PMID: 11771660
DOI: 10.1359/jbmr.2002.17.1.138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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