Article
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine.
Nature genetics - 1 Jul 1998
Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S
Abstract excerpt
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common form of human myelopathy caused by a compression of the spinal cord by ectopic ossification of spinal ligaments. To elucidate the genetic basis for OPLL, we have been studying the ttw (tiptoe walking; previously d...
Topics
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA, Complementary
- Disease Models, Animal
- Female
- Genetic Linkage
- Humans
- Longitudinal Ligaments
- Male
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Ossification of Posterior Longitudinal Ligament
- Pyrophosphatases
- Spine