Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine.

Nature genetics - 1 Jul 1998

Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S

Abstract excerpt

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common form of human myelopathy caused by a compression of the spinal cord by ectopic ossification of spinal ligaments. To elucidate the genetic basis for OPLL, we have been studying the ttw (tiptoe walking; previously designated twy) mouse, a naturally occurring mutant which exhibits ossification of the spinal ligaments very similar to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Complementary
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Mice, Inbred Strains

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 9662402
DOI: 10.1038/956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine.PMID 9662402Read ↗

Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL).Semantic proximity Read ↗

Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine.Semantic proximity Read ↗

Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL).Semantic proximity Read ↗

Isolation of novel mouse genes associated with ectopic ossification by differential display method using ttw, a mouse model for ectopic ossification.Semantic proximity Read ↗

The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms.Semantic proximity Read ↗

Ossification of the posterior longitudinal ligament: genetics and pathophysiology.Semantic proximity Read ↗

Evidence of enhanced expression of osteopontin in spinal hyperostosis of the twy mouse.Semantic proximity Read ↗

The genetics of ossification of the posterior longitudinal ligament.Semantic proximity Read ↗

The Pathogenesis of Ossification of the Posterior Longitudinal LigamentSemantic proximity Read ↗

Progressive paravertebral ligament ossification and pseudoarthrosis in the thoracic spine due to loss of function of the PHEX gene in a patient with X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Ossification of the Posterior Longitudinal Ligament: An Update on Its Biology, Epidemiology, and Natural HistorySemantic proximity Read ↗

Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.