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Functional Characterization of FTDP-17 tau Gene Mutations through Their Effects on Xenopus Oocyte Maturation

1 Mar 2002

Abstract excerpt

tau gene mutations cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Here we have used Xenopus oocyte maturation as an indicator of microtubule function. We show that wild-type four-repeat Tau protein inhibits maturation in a concentration-dependent manner, whereas three-repeat Tau has no effect. Of the seven four-repeat Tau proteins with FTDP-17 mutations tested, five (G272V,...

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PMID: 11756436
DOI: 10.1074/jbc.m107716200

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Functional Characterization of FTDP-17 tau Gene Mutations through Their Effects on Xenopus Oocyte MaturationPMID 11756436Read ↗

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