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Article

O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2002

Liu Zhao-Qian, Zhu Bing, Tan Yun-Fu, Tan Zhi-Rong, Wang Lian-Sheng, Huang Song-Lin, Shu Yan, Zhou Hong-Hao

Abstract excerpt

This work evaluated the kinetic behavior of fluoxetine O-dealkylation in human liver microsomes from different CYP2C19 genotypes and identified the isoenzymes of cytochrome P450 involved in this metabolic pathway. The kinetics of the rho-trifluoromethylphenol (TFMP) formation from fluoxetine was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11752104
DOI: 10.1124/jpet.300.1.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11752104-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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