Article
Increased glycan chain length distribution and decreased susceptibility to moenomycin in a vancomycin-resistant Staphylococcus aureus mutant.
Antimicrobial agents and chemotherapy - 1 Jan 2002
Komatsuzawa Hitoshi, Ohta Kouji, Yamada Sakuo, Ehlert Kerstin, Labischinski Harald, Kajimura Junko, Fujiwara Tamaki, Sugai Motoyuki
Abstract excerpt
A vancomycin-resistant Staphylococcus aureus mutant, COL-VR1 (MIC, 16 microg/ml), was isolated from methicillin-resistant S. aureus COL by exposure to vancomycin. COL-VR1 also showed decreased susceptibility to teicoplanin (8-fold), methicillin (2-fold), macarbomycin (8-fold), and moenomycin (16-fold). Macarbomycin and moenomycin are thought to directly inhibit transglycosylase activity. Characterization of the...
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