Article
A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase C.
The Journal of biological chemistry - 1 Feb 2002
Blumenstein Yakov, Kanevsky Nataly, Sahar Gideon, Barzilai Rachel, Ivanina Tatiana, Dascal Nathan
Abstract excerpt
Human L-type voltage-dependent Ca(2+) channels (alpha(1C), or Ca(v)1.2) are up-regulated by protein kinase C (PKC) in native tissues, but in heterologous systems this modulation is absent. In rat and rabbit, alpha(1C) has two N-terminal (NT) isoforms, long and short, with variable initial segments of 46 and 16 amino acids, respectively. The initial 46 amino acids of the long-NT alpha(1C) are crucial for PKC...
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