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Article

N ε ‐(γ‐ l ‐Glutamyl)‐ l ‐lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease

1 Nov 2001

Abstract excerpt

Pathological-length polyglutamine (Q(n)) expansions, such as those that occur in the huntingtin protein (htt) in Huntington's disease (HD), are excellent substrates for tissue transglutaminase in vitro, and transglutaminase activity is increased in post-mortem HD brain. However, direct evidence for the participation of tissue transglutaminase (or other transglutaminases) in HD patients in vivo is scarce. We now...

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PMID: 11739625
DOI: 10.1046/j.1471-4159.2001.00673.x

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