Article
Haptoglobin phenotype 2-2 overrepresentation in Cys282Tyr hemochromatotic patients.
Journal of hepatology - 1 Dec 2001
Van Vlierberghe H, Langlois M, Delanghe J, Horsmans Y, Michielsen P, Henrion J, Cartuyvels R, Billiet J, De Vos M, Leroux-Roels G
Abstract excerpt
BACKGROUND/AIMS: Patients with genotypic Cys282Tyr homozygous hemochromatosis differ largely in phenotypic presentation. The HFE mutation on itself does not explain the different manifestations of hemochromatosis. We hypothesized that the genetic haptoglobin (Hp) polymorphism, because of its effect on iron metabolism, could be a modifying factor that influences the clinical presentation of hereditary...
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