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Article

Evidence for the high importance of co-morbid factors in HFE C282Y/H63D patients cared by phlebotomies: results from an observational prospective study.

PloS one - 1 Jan 2013

Saliou Philippe, Le Gac Gérald, Mercier Anne-Yvonne, Chanu Brigitte, Guéguen Paul, Mérour Marie-Christine, Gourlaouen Isabelle, Autret Sandrine, Le Maréchal Cédric, Rouault Karen, Nousbaum Jean-Baptiste, Férec Claude, Scotet Virginie

Abstract excerpt

Despite type I haemochromatosis (HC) is mainly associated with the HFE C282Y/C282Y genotype, a second genotype -C282Y/H63D- has mostly been described in other patients. Its association with HC, apart from any associated co-morbid factors, remains unclear and complex to interpret for physicians. This study assesses the weight of this genotype and the role of co-morbid factors in the occurrence of iron overload....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24339903
DOI: 10.1371/journal.pone.0081128
PMCID: PMC3855242

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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