Article
Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.
Genomics - 1 Dec 2001
McCarthy L C, Hosford D A, Riley J H, Bird M I, White N J, Hewett D R, Peroutka S J, Griffiths L R, Boyd P R, Lea R A, Bhatti S M, Hosking L K, Hood C M, Jones K W, Handley A R, Rallan R, Lewis K F, Yeo A J, Williams P M, Priest R C, Khan P, Donnelly C, Lumsden S M, O'Sullivan J, See C G, Smart D H, Shaw-Hawkins S, Patel J, Langrish T C, Feniuk W, Knowles R G, Thomas M, Libri V, Montgomery D S, Manasco P K, Xu C F, Dykes C, Humphrey P P, Roses A D, Purvis I J
Abstract excerpt
We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently...
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