Article
Chromosome 19p13 loci in Finnish migraine with aura families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2005
Kaunisto Mari A, Tikka Päivi J, Kallela Mikko, Leal Suzanne M, Papp Jeanette C, Korhonen Arja, Hämäläinen Eija, Harno Hanna, Havanka Hannele, Nissilä Markku, Säkö Erkki, Ilmavirta Matti, Kaprio Jaakko, Färkkilä Markus, Ophoff Roel A, Palotie Aarno, Wessman Maija
Abstract excerpt
Chromosomal area 19p13 contains two migraine associated genes: a Ca(v)2.1 (P/Q-type) calcium channel alpha(1) subunit gene, CACNA1A, and an insulin receptor gene, INSR. Missense mutations in CACNA1A cause a rare Mendelian form of migraine, familial hemiplegic migraine type 1 (FHM1). Contribution of CACNA1A locus has also been studied in the common forms of migraine, migraine with (MA) and without aura (MO), but...
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