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Article

Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant.

The EMBO journal - 3 Dec 2001

Rao S S, Stewart B A, Rivlin P K, Vilinsky I, Watson B O, Lang C, Boulianne G, Salpeter M M, Deitcher D L

Abstract excerpt

Vesicle fusion in eukaryotic cells is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors). In neurons, the t-SNARE SNAP-25 is essential for synaptic vesicle fusion but its exact role in this process is unknown. We have isolated a SNAP-25 temperature-sensitive paralytic mutant in Drosophila, SNAP-25(ts). The mutation causes a Gly50 to Glu change in SNAP-25's first...

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Identifiers

PMID: 11726512
DOI: 10.1093/emboj/20.23.6761
PMCID: PMC125330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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