Article
Mutant P/Q-type calcium channel electrophysiology and migraine.
Current opinion in investigational drugs (London, England : 2000) - 1 Sept 2001
Plomp J J, van den Maagdenberg A M, Molenaar P C, Frants R R, Ferrari M D
Abstract excerpt
The pathophysiological mechanisms of migraine are not yet very well understood. The gene CACNA1A, coding for the alpha 1A subunit of neuronal P/Q-type Ca2+ channels is mutated in the rare Mendelian inherited variant, familial hemiplegic migraine. This finding suggests a role for disturbed neuronal Ca2+ influx and/or homeostasis in the pathophysiology of migraine. It has stimulated in vitro electrophysiological...
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