Article
Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice.
Molecular and cellular biology - 1 Dec 2001
Ishii N, Owada Y, Yamada M, Miura S, Murata K, Asao H, Kondo H, Sugamura K
Abstract excerpt
AMSH, a molecule that associates with STAM1, is involved in the in vitro cell growth signaling mediated by interleukin 2 and granulocyte-macrophage colony-stimulating factor. To investigate the in vivo functional role of AMSH, we have generated AMSH-deficient mice by gene targeting. The AMSH-deficient mice were morphologically indistinguishable from their littermates at birth, and histopathological examinations...
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