Article
Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.
Biochemical and biophysical research communications - 23 Nov 2001
Kashino G, Kodama S, Suzuki K, Oshimura M, Watanabe M
Abstract excerpt
Werner syndrome (WS) is a premature aging syndrome caused by mutations in the WRN gene. All mutations of the WRN gene reported thus far are predicted to produce the truncated WRN proteins. The mRNAs that contain chain-termination mutations are supposed to be unstable due to degradation by nonsense-mediated mRNA decay (NMD). In the present study, we investigated the expressions of intact and nonsense-mutated WRN...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.