Article
Mitochondrial inheritance in Schistosoma mansoni: mitochondrial variable number tandem repeat mutation produces noise on top of the signal.
The Journal of parasitology - 1 Oct 2001
Bieberich A A, Minchella D J
Abstract excerpt
The Schistosoma mansoni mitochondrial genome contains tandemly arrayed copies of a 62-base repeat motif. The tandem array is highly polymorphic with respect to number of repeats and commonly exhibits heteroplasmy. This study shows that a very high rate of mutation rapidly produces new repeat lengths (new haplotypes) for this mitochondrial variable number tandem repeat. A maternal inheritance pattern is also...
Topics
- Animals
- Biomphalaria
- Blotting, Southern
- Cohort Studies
- Crosses, Genetic
- DNA, Helminth
- Extrachromosomal Inheritance
- Female
- Male
- Mice
- Mice, Inbred BALB C