Article
Circulating nucleic acids in plasma or serum.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2001
Anker P, Lyautey J, Lederrey C, Stroun M
Abstract excerpt
BACKGROUND: Nucleic acids can be found in small amounts in healthy and diseased human plasma/serum. Higher concentrations of DNA are present in the plasma of cancer patients sharing some characteristics with DNA of tumor cells. Together with decreased strand stability, the presence of specific oncogene or tumor-suppressor gene mutations, microsatellite alterations, Ig rearrangements and hypermethylation of...
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