Article
Cell-free nucleic acids in plasma, serum and urine: a new tool in molecular diagnosis
1 Mar 2003
Abstract excerpt
There has recently been an upsurge of interest in the analysis of circulating nucleic acids (DNA and/or RNA) in blood plasma or serum as a clinical diagnostic tool. Occasional earlier reports suggested the existence of circulating nucleic acids, but the potential clinical implication was not realized until 1996, when DNA with tumour-specific characteristics was demonstrated in the plasma/serum of cancer patients....
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