Article
The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2001
Jiang T, Liu S, Tan M, Huang F, Sun Y, Dong X, Guan W, Huang L, Zhou F
Abstract excerpt
BACKGROUND: Glucocorticoid (GC), a mediator of the hypothalamo-pituitary-adrenal axis, has been found to play an important role in maintaining the stability of immune endo-environment of the body. The pathogenesis of lupus nephritis, an autoimmune disease, is thought to be related to the intrinsic hyposensitivity to GC secreted by adrenal gland, and impairs the regulation of the immuno-neuro-endocrine axis....
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