Article
Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.
Transplantation - 27 Oct 2001
Hoffmann S C, Stanley E M, Darrin Cox E, Craighead N, DiMercurio B S, Koziol D E, Harlan D M, Kirk A D, Blair P J
Abstract excerpt
BACKGROUND: Genetic variations in cytokine genes are thought to regulate cytokine protein production. However, studies using T cell mitogens have not always demonstrated a significant relationship between cytokine polymorphisms and in vitro protein production. Furthermore, the functional consequence of a polymorphism at position -330 in the IL-2 gene has not been described. We associated in vitro protein...
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