Article
Clinical and endocrine characteristics in atypical and classical growth hormone insensitivity syndrome.
Hormone research - 1 Jan 2001
Burren C P, Woods K A, Rose S J, Tauber M, Price D A, Heinrich U, Gilli G, Razzaghy-Azar M, Al-Ashwal A, Crock P A, Rochiccioli P, Yordam N, Ranke M B, Chatelain P G, Preece M A, Rosenfeld R G, Savage M O
Abstract excerpt
OBJECTIVE: Classical growth hormone insensitivity syndrome (GHIS) comprises a dysmorphic phenotype, extreme short stature (height SDS < 3), normal GH and low IGF-I and IGFBP-3. Wide clinical variation is recognised with classical and atypical forms. We aimed to delineate features of the milder "atypical" GHIS phenotype, and to determine whether this correlates with milder auxological and biochemical features....
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