Article
Participation of Cbfa1 in regulation of chondrocyte maturation.
Osteoarthritis and cartilage - 1 Jan 2001
Enomoto-Iwamoto M, Enomoto H, Komori T, Iwamoto M
Abstract excerpt
OBJECTIVE: Cbfa1 is a transcription factor, which is classified into the runt family. The mice lacking this gene display complete loss of bone formation, indicating that Cbfa1 is an essential factor for osteoblast differentiation. The Cbfa1-deficient mice also show an abnormality in cartilage development. Although cartilage anlagens are well formed in these mice, endochondral ossification is blocked, and most of...
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