Article
Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS.
Journal of the neurological sciences - 15 Oct 2001
Groeneveld G J, van Kan H J, Toraño J S, Veldink J H, Guchelaar H J, Wokke J H, van den Berg L H
Abstract excerpt
All patients with amyotrophic lateral sclerosis (ALS) are treated with the same dose of riluzole: 50 mg twice daily. Reasonably large interindividual differences in clearance of the drug have been reported. The relatively small group of patients with high blood concentrations of riluzole has probably primarily influenced the efficacy and the incidence of side-effects in the previously conducted clinical trials...
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