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Article

Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype.

Biopharmaceutics & drug disposition - 1 Apr 2008

van Kan H J M, van den Berg L H, Groeneveld G J, van der Straaten R J H M, van Vught P W J, Lie-A-Huen L, Guchelaar H-J

Abstract excerpt

Pharmacokinetic studies of riluzole show a large inter-individual variability of the drug's clearance and serum concentrations. Optimizing the individual dosage of riluzole may have the potential to improve the effect of riluzole treatment on survival of patients with amyotrophic lateral sclerosi...

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PMID: 18098330
DOI: 10.1002/bdd.594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18098330-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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