Article
Codon usage and tRNA genes in eukaryotes: correlation of codon usage diversity with translation efficiency and with CG-dinucleotide usage as assessed by multivariate analysis.
Journal of molecular evolution - 1 Jan 2000
Kanaya S, Yamada Y, Kinouchi M, Kudo Y, Ikemura T
Abstract excerpt
The species-specific diversity of codon usage in five eukaryotes (Schizosaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, and Homo sapiens) was investigated with principal component analysis. Optimal codons for translation were predicted on the basis of tRNA-gene copy numbers. Highly expressed genes, such as those encoding ribosomal proteins and histones in S. pombe, C....
Topics
- Animals
- Base Sequence
- Caenorhabditis elegans
- Codon
- Drosophila melanogaster
- Eukaryotic Cells
- Evolution, Molecular
- Gene Expression
- Genetic Variation
- Humans
- Models, Genetic