Article
Automated mutation screening using dideoxy fingerprinting and capillary array electrophoresis.
Human mutation - 1 Nov 2001
Larsen L A, Johnson M, Brown C, Christiansen M, Frank-Hansen R, Vuust J, Andersen P S
Abstract excerpt
The rapid progress in the isolation of genes associated with human disease has resulted in an increasing demand for mutation screening methods. The molecular diagnosis of the long QT syndrome (LQTS), a cardiac disorder characterized by prolongation of the QT(c) interval in the ECG, syncopes, and sudden death, requires mutation screening of all exons in at least five genes, encoding cardiac Na(+) and K(+) channel...
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